High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors
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چکیده
منابع مشابه
Cyclooxygenase-2 (COX-2) overexpression in childhood brain tumors.
The overexpression of COX enzymes has been demonstrated in human neoplasms at various sites, including the colon, gastrointestinal tract, lung, skin and recently in brain tumors. In this study, COX-2 receptor overexpression in primary childhood brain tumors was determined and the distribution pattern of COX-2 receptors was examined. A sensitive, 4-step, alkaline phosphatase conjugated antigen d...
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Indoleamine 2,3-dioxygenase 1 (IDO1) metabolizes L-tryptophan to kynurenines (KYN), inducing T-cell suppression either directly or by altering antigen-presenting-cell function. Cyclooxygenase (COX)-2, the rate-limiting enzyme in the synthesis of prostaglandins, is over-expressed by several tumours. We aimed at determining whether COX-2 inhibitors down-regulate the IFN--induced expression of ID...
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Hypertensive mice that express the human renin and angiotensinogen genes are used as a model for human hypertension because they develop hypertension secondary to increased renin-angiotensin system activity. Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension. Male (n = 15) and female (...
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Cyclooxygenases (COX, prostaglandin endoperoxide synthases, PGG/H synthases) are potent mediators of edema, impeding blood flow and immunomodulation in the pathologically altered brain. Two COX iso-enzymes have been associated with brain disease, the constitutively expressed COX-1 and the cytokine-inducible COX-2. We have used single and double labeling immunohistochemistry to analyse COX-1 and...
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Professor John Vane won the Nobel Prize for elucidating the mechanism of action of aspirin. He reported that this was accomplished by blocking the enzyme called cyclooxygenase (COX-1) that was responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins liberated from arachidonic acid by cyclooxygenase are short-lived substances that act as local hormones (autocoids) imp...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/21.4.543